Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies

Zachary H Houston; Jens Bunt; Kok-Siong Chen; Simon Puttick; Christopher B Howard; Nicholas L Fletcher; Adrian V Fuchs; Jiwei Cui; Yi Ju; Gary Cowin; Xin Song; Andrew W Boyd; Stephen M Mahler; Linda J Richards; Frank Caruso; Kristofer J Thurecht

Journal article

Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies

Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht

ACS Central Science | American Chemical Society (ACS) | Published : 2020

DOI: 10.1021/acscentsci.9b01299

Abstract

Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of brain tumors where access to the tumor through the vasculature is restricted by the blood–brain barrier (BBB). This makes the application of nanomedicines in neuro-oncology often considered unfeasible, with efficacy limited to regions of significant disease progression and compromised BBB. However, little is understood about how the evolving tumor–brain physiology during disease progression affects the permeability and retention of designer nanomedicines. We report here the development of a modular nanomedicine platform that, when used in conjunction with a uniqu..

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University of Melbourne Researchers

Yi David Ju Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

We kindly acknowledge the financial support from the following funding sources: Tour de Cure (Scott Canner Young Research Grant) to J.B., NHMRC Principal Research Fellowship (GNT1120615) to L.J.R., Australian Government Research Training Program Scholarship, Ride for Rhonda, and Brain Foundation, and National Health and Medical Research Council Project Grant (APP1099321) and Career Development Fellowship 2 for K.J.T. (APP1148582). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (F.C., APP1135806). This work was conducted in part through the ARC Centre of Excellence in Convergent BioNano Science and Technology (CE140100036) and the ARC Training Centre for Innovation in Biomedical Imaging Technologies (IC170100035).